Genetic factors influencing the risk of multiple myeloma bone disease
نویسندگان
چکیده
منابع مشابه
MULTIPLE MYELOMA Myeloma bone disease
Bone destruction is a hallmark of multiple myeloma, and recent studies demonstrated a strong interdependence between tumor progression and bone resorption. Increased bone resorption as a major characteristic of multiple myeloma is caused by osteoclast activation and osteoblast inhibition (uncoupling). Myeloma cells alter the local regulation of bone metabolism by increasing the receptor activat...
متن کاملBone Disease in Multiple Myeloma
Osteolytic bone disease in multiple myeloma (MM) is a common event. Already at diagnosis, approximately eighty percent of patients present with abnormal bone structure [1;2]. During disease progression a large proportion of patients will develop ostelytic lesions [3]. MM bone disease not only results in a reduced quality of life due to pain, pathological fractures, or symptomatic hypercalcaemia...
متن کاملBone disease in multiple myeloma.
Multiple myeloma is a uniformly fatal hematologic malignancy that results from the clonal expansion of plasma cells within the bone marrow. Skeletal-related complications affect nearly all patients with multiple myeloma and have a major impact on both patient morbidity and mortality. These complications most frequently include the development of osteolytic lesions that lead to severe bone pain,...
متن کاملCellular Mechanisms of Multiple Myeloma Bone Disease
Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. MM osteolytic b...
متن کاملFactors influencing extramedullary relapse after allogeneic transplantation for multiple myeloma
Patients undergoing allogeneic stem cell transplantation (allo-SCT) with reduced intensity conditioning (RIC) for multiple myeloma (MM) experience a high frequency of extra-medullary relapses (EMR) (20–37%). This study aims at determining factors predictive for EMR after allo-SCT, prognosis of EMR and efficacy of salvage therapies. We retrospectively analyzed a continuous cohort of 79 patients ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2015
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2015.342